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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Hepatology. 2013 Sep 30;58(5):1713–1723. doi: 10.1002/hep.26554

Figure 5. In Pkhd1del4/del4 cholangiocytes, nuclear translocation of p675-β-catenin is Rac-1-dependent.

Figure 5

Representative Western blots and quantitative analyses on cytosolic (A) and on nuclear (B) cell lysates. In Pkhd1del4/del4 cholangiocytes, but not in WT or PC-KO, forskolin (F) augmented the expression of p675-β-catenin. Treatment with the Rac-1 inhibitor, NSC 23766 (NSC), significantly blocked the expression of p675-β-catenin in the nuclear fraction. (n=4, *p<0.05 vs untreated cells (C); ○p<0.05 vs forskolin)