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WT and Pkhd1del4/del4 cholangiocytes were transfected with a TCF/LEF Top Flash reporter or its mutant, Fop Flash. Luciferase activity was normalized to Renilla luciferase activity. Treatment with the Rac-1 inhibitor, NSC 23766, significantly inhibited the transcriptional activity of β-catenin. (n=6; *p<0.05 vs untreated cells (C); ○p<0.05 vs forskolin (F).
