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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Neuron. 2013 Jul 24;79(2):335–346. doi: 10.1016/j.neuron.2013.05.016

Fig 8. Differential response of NARP −/− mice to low versus high frequency visual stimulation.

Fig 8

A. High frequency visual stimulation (10 Hz reversals of 0.04 cycle/degree 100% contrast vertical gratings) induced a rapid increase in VEP amplitude in P30 wild type and NARP −/− mice, but 5 Hz reversals were ineffective *=p<0.05 t-test versus pre-stimulation baseline. B. Enhancement of VEP amplitude following high frequency visual stimulation did not transfer to a visual stimulus of a novel orientation. C. Low frequency visual stimulation (1 Hz reversals of 0.04 cycle/degree 100% contrast vertical gratings) induced a slow increase in VEP amplitude in P30 wild type mice (black symbols), which was inhibited by diazepam (15 mg/kg, i.p; 30 mins prior to stimulation; green symbols). Two way repeated measures ANOVA: F1,8=18.288, p=0.003; *p<0.01 Bonferroni’s post hoc versus pre-stimulation. D. Enhancement of VEP amplitudes following low frequency visual stimulation did not transfer to a visual stimulus of a novel orientation. E. Low frequency visual stimulation (1 Hz reversals of 0.04 cycle/degree 100% contrast vertical gratings) did not change VEP amplitudes in P30 NARP −/− mice (red symbols). Administration of diazepam (30 mins prior to stimulation), enabled the enhancement of VEP amplitudes by low frequency visual stimulation (blue symbols; 15 mg/kg, i.p.). Two way repeated measures ANOVA: F1,8=12.247, p=0.008; *p<0.01 Bonferroni’s post hoc versus pre-stimulation. F. The enhancement of VEP amplitudes in NARP −/− mice by low frequency visual stimulation enabled by diazepam, did not transfer to a visual stimulus of a novel orientation.