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. 1996 Oct 15;93(21):11307–11312. doi: 10.1073/pnas.93.21.11307

The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors.

B Roizman 1
PMCID: PMC38053  PMID: 8876131

Abstract

Herpes simplex virus vectors are being developed for delivery and expression of human genes to the central nervous system, selective destruction of cancer cells, and as carriers for genes encoding antigens that induce protective immunity against infectious agents. Vectors constructed to meet these objectives must differ from wild-type virus with respect to host range, reactivation from latency, and expression of viral genes. The vectors currently being developed are (i) helper free amplicons, (ii) replication defective viruses, and (iii) genetically engineered replication competent viruses with restricted host range. Whereas the former two types of vectors require stable, continuous cell lines expressing viral genes for their replication, the replication competent viruses will replicate on approved primary human cell strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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