Fig. 4. IL-6 promotes peripheral T cell homeostasis.

(A) LN T cell numbers in IgH^KO and IgH^KOIL6^Tg mice. Data show the mean +/− SEM of five independent experiments with a total of seven IgH^KO and eight IgH^KOIL6^Tg mice.

(B) LN cell analysis of IgH^KO and IgH^KOIL6^Tg mice. Histograms show TCRβ expression of total LN cells (top). Contour plots show CD4/CD8 profiles of TCRβ⁺ gated LN T cells. Results are representative of five independent experiments with seven IgH^KO and eight IgH^KOIL6^Tg mice.

(C) CD4/CD8 ratio of LN T cells. Data show mean +/− SEM of four independent experiments with a total of seven IgH^KO and six IgH^KOIL6^Tg mice.

(D) Cytokine receptor expression on IgH^KO and IgH^KOIL6^Tg T cells. Surface IL-6Rα and IL-7Rα levels were quantified in MFI. Bar graphs show the mean +/− SEM of four independent experiments with seven IgH^KO and six IgH^KOIL6^Tg mice.