Skip to main content
NCBI home page
Applied Microbiology logoLink to Applied Microbiology
. 1973 May;25(5):755–762. doi: 10.1128/am.25.5.755-762.1973

Resistance to Arbovirus Challenge in Mice Immediately After Vaccination

Jordi Casals 1, Sonja M Buckley 1, David W Barry 1
PMCID: PMC380907  PMID: 4577178

Abstract

Mice vaccinated with a single injection of formalin-inactivated suspensions of mouse brain tissue infected with arboviruses were markedly protected against a challenge injection administered hours later. The protection observed during the first 2 days after vaccination seemed to be nonspecific, in that it appeared not only with the homologous system but also between arboviruses of different antigenic groups; this phase may be associated with an interferon-like activity of the serum. Overlapping the nonspecific phase was one of specific protection, which seemed to be well-established in its own right by day 3 or 4 after vaccination. Serum neutralizing antibodies against the homologous viruses were detected as early as 24 h after vaccination and in almost all instances by day 3.

Full text

PDF
755

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baer G. M., Cleary W. F. A model in mice for the pathogenesis and treatment of rabies. J Infect Dis. 1972 May;125(5):520–527. doi: 10.1093/infdis/125.5.520. [DOI] [PubMed] [Google Scholar]
  2. FORCE E. E., STEWART R. C., HAFF R. F. DEVELOPMENT OF INTERFERON IN RABBIT DERMIS AFTER INFECTION WITH HERPES SIMPLEX VIRUS. Virology. 1965 Feb;25:322–325. doi: 10.1016/0042-6822(65)90210-2. [DOI] [PubMed] [Google Scholar]
  3. HEARN H. J., Jr, RAINEY C. T. CROSS-PROTECTION IN ANIMALS INFECTED WITH GROUP A ARBOVIRUSES. J Immunol. 1963 May;90:720–724. [PubMed] [Google Scholar]
  4. Karabatsos N. Characterization of viruses isolated from bats. Am J Trop Med Hyg. 1969 Sep;18(5):803–810. doi: 10.4269/ajtmh.1969.18.803. [DOI] [PubMed] [Google Scholar]
  5. Libíková H., Buckley S. M. Serological characterization of Eurasian Kemerovo group viruses. II. Cross plaque neutralization tests. Acta Virol. 1971 Jan;15(1):79–86. [PubMed] [Google Scholar]
  6. Murphy B. R., Glasgow L. A. Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice. J Exp Med. 1968 May 1;127(5):1035–1052. doi: 10.1084/jem.127.5.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Price W. H., Thind I. S., O'Leary W., el Dadah A. H. A protective mechanism induced by live group B arboviruses against heterologous group B arboviruses independent of serum neutralizing antibodies or interferon. Am J Epidemiol. 1967 Jul;86(1):11–27. doi: 10.1093/oxfordjournals.aje.a120716. [DOI] [PubMed] [Google Scholar]
  8. SVEHAG S. E., MANDEL B. THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. I. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN KINETICS AND ANTIGEN DOSE REQUIREMENT FOR INDUCTION. J Exp Med. 1964 Jan 1;119:1–19. doi: 10.1084/jem.119.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Simizu B., Rhim J. S., Wiebenga N. H. Characterization of the Tacaribe group of arboviruses. I. Propagation and plaque assay of Tacaribe virus in a line of African green monkey kidney cells (Vero). Proc Soc Exp Biol Med. 1967 May;125(1):119–123. doi: 10.3181/00379727-125-32029. [DOI] [PubMed] [Google Scholar]
  10. UHR J. W., FINKELSTEIN M. S., BAUMANN J. B. Antibody formation. III. The primary and secondary antibody response to bacteriophage phi X 174 in guinea pigs. J Exp Med. 1962 Mar 1;115:655–670. doi: 10.1084/jem.115.3.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wiktor T. J., Koprowski H., Rorke L. B. Localized rabies infection in mice. Proc Soc Exp Biol Med. 1972 Jul;140(3):759–764. doi: 10.3181/00379727-140-36547. [DOI] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES