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. 1973 May;25(5):763–769. doi: 10.1128/am.25.5.763-769.1973

Tissue Distribution and Metabolism of Aflatoxin B1-14C in Broiler Chickens

Michael S Mabee 1, John R Chipley 1
PMCID: PMC380908  PMID: 4715554

Abstract

The effects of administering low levels of aflatoxin B1-14C by crop intubation daily for 14 days to broiler chickens were determined. Studies on the distribution of 14C in the blood, selected organs, tissues, and excreta were conducted. No toxic effects were observed in broiler chickens during the 14 days of the experiment. The broiler chickens excreted 90.64% of the 14C administered. Of the 14C retained, 11.04, 9.83, 4.30, 12.52, 31.66, and 30.63% were detected in the blood, liver, heart, gizzard, breast, and leg, respectively. Chemical assay of those samples demonstrating radioactivity revealed that 81.2% of the radioactivity in these substrates was not extractable by classical extraction procedures while approximately 10% was extractable. Treatment of aqueous extracts for conjugated steroids by treatments with beta-glucuronidase revealed that 31.5% of the 14C detected in the aqueous extract was a liberated glucuronide conjugate of aflatoxin M1-14C.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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