Figure 2. Spatiotemporal control of cellular strategies at the future interconnection zone. (A-D) Schematics highlighting cellular mechanisms occurring at the future site of luminal interconnections. (A) Basement membrane dissolution. Basal lamina shown in either thick green or red lines between two epithelial tubes. (B) Selected burst of apoptosis at juxtaposed cells located at the future site of luminal interconnection (hypothetical apoptotic cells depicted in magenta colored nuclei that may occur at either end of each tubular networks). (C) Cell rearrangements and reorganization of epithelial junctions. Tight junction complexes indicated in blue. (D) Invasive behaviors emerging from one tubular network at the future site of luminal interconnection (labeled in green).