Skip to main content
. 2013 Nov;195(3):899–913. doi: 10.1534/genetics.113.154393

Figure 6.

Figure 6

ABL-1 signals in VAB-1-dependent amphid axon guidance. (A) Quantification of amphid axon guidance defects in abl-1 mutants. (B) Synergism of guidance defects in the vab-1(kd) abl-1 age-1 triple mutant suggests ABL-1 and PI3K act in parallel and are redundant with VAB-1 kinase signaling. (C) dyf-7 driven (panamphid) expression of ABL-1 (juEx4345) rescues abl-1 enhancement of vab-1(kd) guidance defects but not vab-1(0) defects. str-1-driven AWB-specific expression of ABL-1 (juEx5059) suppresses the vab-1(kd) abl-1(ok171) double mutant and the vab-1(kd) single mutant. (D) Rescue of guidance of multiple amphid axons by expression of ABL-1 in AWB. Images of vab-1(kd); abl-1; Pstr-1-ABL-1 kyIs104 transgenic animals with other amphid axons visualized by DiI staining. Guidance of AWB correlates with guidance of other amphid axons in nonrescued and rescued animals (N > 50 axons). Statistics, Fisher exact test: *P < 0.05; **P < 0.01; ***P < 0.001.