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Our current model. During metaphase I arrest, Cdk1 maintains the activity of Mos. This maintains the MEK/MAPK pathway active and suppresses the APC/C. After egg activation, calcineurin and PP2A activate the APC/C through dephosphorylation, initially in the continuing presence of MAPK activity. As the increase in APC/C activity causes inactivation of Cdk1, Mos is inactivated and so MEK/MAPK activity falls.
