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. 2012 Jun 6;32(6):337–342. doi: 10.3233/DMA-2012-0896

Limited Value of KAI1/CD82 Protein Expression as a Prognostic Marker in Human Gastric Cancer

Maximilian Knoener 1, Till Krech 1, Florian Puls 1, Ulrich Lehmann 1, Hans Kreipe 1, Matthias Christgen 1,*
PMCID: PMC3826928  PMID: 22684230

Abstract

The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n = 271) with amean clinical follow-up time of 48months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p = 0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p = 0.0222), metastatic lymph node involvement (p = 0.0018) and a higher clinical tumor stage (p = 0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p = 0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.

Keywords: Gastric cancer, prognostic markers, metastasis, immunohistochemistry

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