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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Jan;76(1):435–437. doi: 10.1073/pnas.76.1.435

Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

W M Generoso, K T Cain, M Krishna, S W Huff
PMCID: PMC382954  PMID: 284360

Abstract

Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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