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. 1979 Jan;76(1):473–475. doi: 10.1073/pnas.76.1.473

Incorporation of glucocerebrosidase into Gaucher's disease monocytes in vitro.

G L Dale, W Kuhl, E Beutler
PMCID: PMC382963  PMID: 284362

Abstract

Several carriers were evaluated for use in the delivery of exogenous glucocerebrosidase to monocytes from Gaucher's disease patients. Only gamma globulin-coated, resealed erythrocytes proved to be an effective vehicle for enzyme delivery. Glucocerebrosidase added in this manner normalized intracellular enzyme levels for at least 18 hr. In this model system for the study of enzyme replacement therapy, soluble enzyme, enzyme in uncoated resealed erythrocytes, and enzyme incorporated into liposomes were ineffective.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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