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. 1979 Feb;76(2):580–584. doi: 10.1073/pnas.76.2.580

Nucleotide sequence of the origin of replication of the Escherichia coli K-12 chromosome.

M Meijer, E Beck, F G Hansen, H E Bergmans, W Messer, K von Meyenburg, H Schaller
PMCID: PMC382992  PMID: 370833

Abstract

The origin of replication, oriC, of the Escherichia coli chromosome was mapped within a DNA segment of 422 base pairs. The nucleotide sequence of this segment was determined. The source of DNA for the sequence analysis was a minichromosome constructed in vivo, consisting exclusively of chromosomal DNA and a minichromosome constructed by cloning in vitro. The nucleotide sequence of the replication origin is characterized by a high degree of repetitiveness due to both inverted and direct repeats. Sequence homologies were found between portions of the replication origins of E. coli and phages lambda and G4. This suggests similarities in some steps in the initiation of replication of the different replicons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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