Abstract
Two experiments were conducted for testing frequency-dependent selection at the alcohol dehydrogenase locus (Adh; map position, 2--50.1), where two types of alleles, AdhF and AdhS, have been found to be polymorphic in natural populations. First, a competition experiment was carried out between inversion-free AdhF/AdhF and AdhS/AdhS genotypes at five gene frequency levels (those of AdhF = 0.83, 0.67, 0.5, 0.33, and 0.17). First-instar larvae of the two homozygous types in various ratios were placed in a vial, and the frequency of adult flies of each genotype was determined. However, the relative viabilities of these two types did not change with the change in the frequencies of genotypes or genes. The second test was performed by using the results of viability tests with the Cy method of Wallace, using the results of inversion-free crosses only. Although there was variation in the gene frequencies among the vials in testing the viability of individuals consistng of random combinations of two second chromosomes, no difference was found in average viabilities among the vials in which the gene frequencies were different. Thus, no evidence for frequency-dependent selection was obtained.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dolan R., Robertson A. The effect of conditioning the medium in DRosophila, in relation to frequency-dependent selection. Heredity (Edinb) 1975 Dec;35(3):311–316. doi: 10.1038/hdy.1975.102. [DOI] [PubMed] [Google Scholar]
- Huang S. L., Singh M., Kojima K. A Study of Frequency-Dependent Selection Observed in the Esterase-6 Locus of DROSOPHILA MELANOGASTER Using a Conditioned Media Method. Genetics. 1971 May;68(1):97–104. doi: 10.1093/genetics/68.1.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kojima K. I., Tobari Y. N. The pattern of viability changes associated with genotype frequency at the alcohol dehydrogenase locus in a population of Drosophila melanogaster. Genetics. 1969 Jan;61(1):201–209. doi: 10.1093/genetics/61.1.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kojima K., Yarbrough K. M. FREQUENCY-DEPENDENT SELECTION AT THE ESTERASE 6 LOCUS IN Drosophila melanogaster. Proc Natl Acad Sci U S A. 1967 Mar;57(3):645–649. doi: 10.1073/pnas.57.3.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewontin R. C., Ginzburg L. R., Tuljapurkar S. D. Heterosis as an explanation for large amounts of genic polymorphism. Genetics. 1978 Jan;88(1):149–169. doi: 10.1093/genetics/88.1.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDonald J. F., Ayala F. J. Genetic and biochemical basis of enzyme activity variation in natural populations. I. Alcohol dehydrogenase in Drosophila melanogaster. Genetics. 1978 Jun;89(2):371–388. doi: 10.1093/genetics/89.2.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morgan P. Frequency-dependent selection at two enzyme loci in Drosophila melanogaster. Nature. 1976 Oct 28;263(5580):765–766. doi: 10.1038/263765a0. [DOI] [PubMed] [Google Scholar]
- Mukai T., Yamaguchi O. The genetic structure of natural populations of Drosophila melanogaster. XI. Genetic variability in a local population. Genetics. 1974 Feb;76(2):339–366. doi: 10.1093/genetics/76.2.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Muki T., Watanabe T. K., Yamaguchi O. The genetic structure of natural populations of Drosophila melanogaster. XII. Linkage disequilibrium in a large local population. Genetics. 1974 Aug;77(4):771–793. doi: 10.1093/genetics/77.4.771. [DOI] [PMC free article] [PubMed] [Google Scholar]