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. 1996 Sep 17;93(19):10012–10017. doi: 10.1073/pnas.93.19.10012

Dendrimer-supported combinatorial chemistry.

R M Kim 1, M Manna 1, S M Hutchins 1, P R Griffin 1, N A Yates 1, A M Bernick 1, K T Chapman 1
PMCID: PMC38327  PMID: 11607705

Abstract

A new methodology for the construction of combinatorial libraries is described. The approach, termed dendrimer-supported combinatorial chemistry (DCC), centers on the use of dendrimers as soluble supports. Salient features of DCC include solution phase chemistry, homogeneous purification, routine characterization of intermediates, and high support loadings. To demonstrate the feasibility of DCC, single compounds and a small combinatorial library were prepared via the Fischer indole synthesis. Excellent product yields and purities were obtained, and dendrimer-protected intermediates could be routinely analyzed by 1H and 13C NMR and by mass spectrometry. The results indicate that DCC is a general and efficient strategy for the generation of combinatorial libraries.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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