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. 1979 Apr;76(4):1532–1536. doi: 10.1073/pnas.76.4.1532

Conformation of uncomplexed natural antamanide crystallized from CH3CN/H2O

Isabella L Karle *, T Wieland †, D Schermer †, H C J Ottenheym ‡
PMCID: PMC383422  PMID: 16592635

Abstract

Natural antamanide, a cyclic decapeptide from Amanita phalloides, has been shown to have the same conformation for the backbone and comparable side groups as the biologically active synthetic [Phe4, Val6]antamanide. Packing in the crystal is quite different for the two compounds. Large channels with a polar lining are formed in the crystals of [Phe4, Val6]antamanide, whereas in natural antamanide large channels in the crystal are completely surrounded by the lipophilic side groups of the Pro, Phe, and Ala residues. Antamanide, C64H78N10O10·8H2O·X, crystallizes in space group P212121 with a = 15.88 Å, b = 34.88 Å, and c = 13.61 Å.

Keywords: bound water, solvent channels, hydrogen bonds, x-ray analysis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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