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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Apr;76(4):1793–1794. doi: 10.1073/pnas.76.4.1793

Induction of rat sarcomas in rats treated with antithymocyte sera after transplantation of human cancer cells.

R J Huebner, D C Fish, D Djurickovic, R W Trimmer, A L Bare, R M Bare, G T Smith
PMCID: PMC383477  PMID: 287020

Abstract

Human cancer cells that had had high (greater than 160) tissue culture passages, when transplanted into antithymocyte-treated F344 newborn rats, caused induction of rat sarcomas in the rats within 2 or 3 subcultures, whereas human cancer cells with low (5-33) passages in vitro did not cause overt induction of rat sarcomas until after 5-10 subtransplantations. Because oncornavirus activity was not detected in either rat or human tumors, it is suggested that transforming sequences located on the human tumor cells may have been transferred to supporting rat reticulum cells in close contact with the human cancer cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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