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pH measurements during solubility and dissolution studies.
| Formulation | ||||
|---|---|---|---|---|
| pH measurement | TMP free base | TMP Aspartate | TMP glutamate | |
| Solubility study (Equilibrium) | 7.7 ± 0.05 | 5.075 ± 0.06 | 5.2 ± 0.11 | |
| End of dissolution study | 8.6 ± 0.07 | 5.37 ± 0.08 | 5.88 ± 0.05 | |
