Table 1.
Permeation parameters of the diclofenac salts.
| Diclofenac Salts | J (μg cm−2 h−1) | Q8 (μg cm−2) × 103 | S1 (μg cm−3) × 103 | D (cm h−1) × 103 | logP (salt) | logP (free base) | S2 (mM) | pKa (base) | pH * (sat. sol.) |
|---|---|---|---|---|---|---|---|---|---|
| MEtA | 12 | 9.3 | 6.1 | 2 | 0.01 | −0.13 | 17.9 | 10.84 | 7.62 |
| MEA | 6.9 | 5.6 | 9.9 | 0.7 | 0.08 | −1.31 | 26.4 | 9.50 | 6.95 |
| DEtA | 48 | 1.9 | 13.7 | 3.7 | 0.17 | 0.58 | 35.4 | 10.75 | 7.58 |
| DEA | 51 | 1.8 | 18.0 | 2.8 | 0.08 | −1.43 | 44.9 | 8.97 | 6.68 |
| TEtA | 23 | 0.6 | 6.7 | 3.4 | 0.85 | 1.45 | 16.1 | 10.75 | 7.58 |
| TEA | 20 | 0.6 | 3.4 | 3.0 | 0.64 | −1.59 | 7.6 | 7.76 | 6.08 |
| M | 26 | 1.1 | 6.9 | 3.8 | 0.35 | −0.72 | 18.0 | 8.50 | 6.45 |
| HEM | 21 | 0.3 | 4.4 | 4.8 | 1.04 | −0.489 * | 9.7 | 6.89 | 5.64 |
| Pz | 18 | 0.1 | 0.4 | 45 | 0.67 | −1.17 | 0.59 | 4.19 | 4.29 |
| HEPz | 160 | 0.4 | 12.5 | 13 | 0.24 | −0.957 * | 29.3 | 9.05 | 6.72 |
| PP | 87 | 0.6 | 4.3 | 20 | 0.97 | 0.80 | 11.3 | 11.12 | 7.75 |
| HEPp | 82 | 0.9 | 10.7 | 7.7 | 0.29 | 0.449 * | 25.2 | 9.66 | 7.03 |
| Py | 42 | 0.3 | 2.0 | 21 | 0.21 | 0.46 | 5.1 | 11.32 | 7.85 |
| HEPy | 194 | 1.5 | 20.2 | 9.6 | 0.17 | 0.076 * | 45.2 | 9.72 | 7.06 |
| Na | 0.58 ** | ||||||||
| 1.3 *** | |||||||||
| Acid | 3500 *** |
* calculated values; ** ref. [25]; *** ref. [19]; Abbreviations: J, flux; Q8, amount permeated after 8h; S1 and S2, solubility reported in terms of micrograms per milliliter and millimoles per liter.; D, permeation coefficient; logP, decimal logarithm of the partition coefficient for the free base or for the diclofenac salt; pKa, negative logarithm of the acidity constant of the base; pH, calculated value of the saturated solution.