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. 1979 Apr;76(4):1916–1920. doi: 10.1073/pnas.76.4.1916

Biochemical and electron microscopic evidence that cell nucleus negatively controls mitochondrial genomic activity in early sea urchin development.

A M Rinaldi, G De Leo, A Arzone, I Salcher, A Storace, V Mutolo
PMCID: PMC383503  PMID: 287031

Abstract

Enucleated halves of sea urchin eggs obtained by centrifugation contain almost all the mitochondrial population of the egg. Removal of the nucleus followed by parthenogenetic activation stimulates the incorporation of [3H]thymidine into the mitochondrial DNA, whereas no such incorportion is observed in activated whole eggs. The block is not the result of a modification in the permeability of the mitochondrial membrane. Electron microscopic observations demonstrated duplication of mitochondrial DNA molecules in activated enucleated halves. No duplication was found in the mitochondrial DNA from activated whole eggs or from nonactivated enucleated halves. We conclude that the cell nucleus exerts a negative control on the activity of the mitochondrial genome through some short-lived nuclear substance(s).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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