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. 1979 May;76(5):2410–2414. doi: 10.1073/pnas.76.5.2410

Pregnant mice are not primed but can be primed to fetal alloantigens.

T G Wegmann, C A Waters, D W Drell, G A Carlson
PMCID: PMC383611  PMID: 287081

Abstract

In this report we present evidence gathered from various stages of murine pregnancy that indicates that pregnant females have no demonstrable immune effector function directed against their semiallogeneic fetuses. Specifically, by using in vitro assays we found that cytotoxic lymphocytes were not present in pregnant mice, and pregnant mice challenged with radiolabeled paternal strain leukemia cells showed no evidence of immune elimination. Nonetheless, immunity measurable both in vitro and in vivo was readily induced by priming with the paternal strain cells. No harm to the fetus was observed in primed mothers. These results cast doubt on the relevance of mechanisms proposed that involve systemic active suppression during pregnancy. The results are compatible with the hypothesis that the placenta acts as a barrier, preventing fetal cells from priming the mother.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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