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. 1979 May;76(5):2430–2433. doi: 10.1073/pnas.76.5.2430

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

D A Carson, J Kaye, S Matsumoto, J E Seegmiller, L Thompson
PMCID: PMC383615  PMID: 313056

Abstract

Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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