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Kinetic Parameters for Inhibition of B. anthracis IMPDH by XMP and MPA
| inhibitor | inhibition patterna | Kis (μM) | Kii (μM) | |
|---|---|---|---|---|
| XMP | vs IMPb | C | 218 ± 6 | nac |
| MPA | vs IMPb | NC | nac | 4.83 ± 0.04 |
| MPA | vs NAD+ d | NC | nac | 3.9 ± 0.2 |
C, competitive; NC, noncompetitive.
NAD+ concentration fixed at 1.3 mM.
Not applicable.
IMP concentration fixed at 750 μM.
