Table 4.

Comparison of the Histologic Changes in Non-neoplastic Pancreatic Tissue between the Treated and Control Groups

Histologic parameter	Treated group (n=218)	Control group (n=65)	P value
Fibrosis and atrophy			<0.001
Absent	0 (0%)	12 (18.5%)
Mild	10 (4.6%)	29 (44.6%)
Moderate	149 (68.3%)	18 (27.7%)
Severe	59 (27.1%)	6 (9.2%)
Islet cell aggregation			<0.001
Present	79 (36.2%)	5 (7.7%)
Absent	139 (63.8%)	60 (92.3%)
Inflammation			0.02
Grade 0	103 (47.3%)	23 (35.4%)
Grade 1	86 (39.4%)	21 (32.3%)
Grade 2	29 (13.3%)	21 (32.3%)
Neuroma-like nerve proliferation			0.005
Present	34 (15.6%)	2 (3.1%)
Absent	184 (84.4%)	63 (96.9%)