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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Jun;76(6):2735–2739. doi: 10.1073/pnas.76.6.2735

Chromosomal assignment of the mouse kappa light chain genes.

D Swan, P D'Eustachio, L Leinwand, J Seidman, D Keithley, F H Ruddle
PMCID: PMC383683  PMID: 111241

Abstract

Mouse-hamster somatic cell hybrids containing a variable number of mouse chromosomes have been used in experiments to determine which mouse chromosome carries the immunoglobulin kappa light chain genes. It has been shown by nucleic acid hybridization that the kappa constant gene and the genes for at least one variable region subgroup are on mouse chromosome 6. This somatic cell genetic mapping procedure appears to be general and can be applied to any expressed or silent gene for which an appropriate nucleic acid probe exists.

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Selected References

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