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. 1979 Jun;76(6):2908–2911. doi: 10.1073/pnas.76.6.2908

Endogenous oncornaviral antigen in the bursa of Fabricius of 15B X 7(2) chickens.

J M England, M S Halpern
PMCID: PMC383719  PMID: 379867

Abstract

Oncornaviral antigen was detected in the bursal epithelium and in a subpopulation of bursal follicular cells of 15B X 72 chickens. This antigen is present in the bursal epithelium at 11 days of embryogenesis and persists there for at least 3 weeks after hatching. The absence of detectable antigen in the intestinal epithelium contiguous to the bursal epithelium indicates that the accumulation of viral antigen is a specific property of the bursal epithelium. The observation of C-type particles in the intraepithelial spaces suggests that the viral antigen in synthesized and assembled into virions by the bursal epithelial cells. In embryonic bursas, viral antigen-positve cells radiate from the surface epithelium toward the central region of the follicles. In bursas from post-hatch chickens, viral antigen-positive cells, including intrafollicular epithelial cells and cells resembling lymphocytes, are confined to the medullary region of the follicles.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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