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. 1979 Jul;76(7):3111–3115. doi: 10.1073/pnas.76.7.3111

Binding of ribosomes to 5'-terminal leader sequences of eukaryotic messenger RNAs.

W Filipowicz, A L Haenni
PMCID: PMC383773  PMID: 290990

Abstract

Tobacco mosaic virus and turnip yellow mosaic virus genome RNAs, which have long (greater than or equal to 69 nucleotides) 5'-terminal leader sequences preceding the AUG initiation codon, can form disome initiation complexes when incubated with a wheat germ extract and sparsomycin. In tobacco mosaic virus RNA, whereas one ribosome in such complexes presumably occupies the AUG-containing initiation site, the other is located within the RNA leader sequence. The results favor a model of eukaryotic initiation in which ribosomes first bind to the 5' end of the mRNA independently of AUG, then advance to the AUG initiation codon, where protein synthesis ensues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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