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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Jul;76(7):3547–3551. doi: 10.1073/pnas.76.7.3547

Degradation of junctional and extrajunctional acetylcholine receptors by developing rat skeletal muscle.

J H Steinbach, J Merlie, S Heinemann, R Bloch
PMCID: PMC383865  PMID: 291023

Abstract

We have examined the rate of degradation of the total acetylcholine receptor content of diaphragm muscles of young rats and have found that even in muscles from 1-day-old rats some receptors are metabolically more stable than adult extrajunctional receptors. Further experiments have shown that acetylcholine receptors at junctional regions from young rats are degraded slowly, whereas those in extrajunctional regions are degraded rapidly. The results demonstrate that junctional acetylcholine receptors in rat diaphragm are degraded at a slow rate characteristic of adult junctional receptors at all ages after birth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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