Figure 4. Rev-erbα orchestrates daily rhythms of body temperature and BAT activity.

a, Core (n=6) and, b, BAT (n=10) temperatures measured from subcutaneously implanted thermometers. c, Quantified thermographic measurements of surface temperature (n=5) and, d, 18-fluorodeoxyglucose (¹⁸FDG) imaging (n=4) of Rev-erbα KO mice and WT littermates during the light and dark phases. Representative coronal planes are shown for each group. e, Percent injected dose of ¹⁸FDG in the BAT of animals from the study in 4d. * p<0.05, ** p<0.01, *** p <0.001 as determined by two-tailed Student’s t-test or one-way ANOVA with multiple comparisons and a Tukey post-test. Data in 4a are expressed as rolling averages (±2 time points) ± s.e.m.; data in 4b are expressed as mean ± s.e.m.; data in 4c are expressed as a max to min box-and-whiskers plot; data in 4e are expressed as a mean ± s.d.