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. 1979 Aug;76(8):4136–4140. doi: 10.1073/pnas.76.8.4136

Selection of variant neuroblastoma clones with missing or altered sodium channels.

G J West, W A Catterall
PMCID: PMC383993  PMID: 291071

Abstract

Neurotoxins that cause persistent activation of voltage-sensitive sodium channels are highly cytotoxic to electrically excitable neuroblastoma cells. These toxins were used as selective agents to isolate variant neuroblastoma clones with missing or altered sodium channels. Of ten resistant clones analyzed, seven lacked functional sodium channels and one had a specific 40-fold increase Kd for scorpion toxin and altered voltage dependence of scorpion toxin binding. The phenotypes of these cell clones were stable for more than 100 generations, indicating that they were the result of stable genetic change.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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