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. 1983 Jul;80(14):4306–4310. doi: 10.1073/pnas.80.14.4306

Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.

A Raibaud, C Gaillard, S Longacre, U Hibner, G Buck, G Bernardi, H Eisen
PMCID: PMC384026  PMID: 6308614

Abstract

Expression of variant antigen genes in Trypanosoma equiperdum is accompanied by the duplication of a silent basic copy gene and the transposition of the copy to an expression site elsewhere in the genome. We have analyzed the genomic locations of both the basic and expression-linked copies of the T. equiperdum gene for variable surface glycoprotein VSG-1. Both copies are situated proximal to termini in both extracted DNA and in chromatin. The regions between the VSG-1 genes and the termini have a very high buoyant density in CsCl and contain an unidentified nucleoside that replaces deoxycytidine.

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