Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1996 Sep 17;93(19):10495–10499. doi: 10.1073/pnas.93.19.10495

Nonlinear dynamics in ventricular fibrillation.

H M Hastings 1, S J Evans 1, W Quan 1, M L Chong 1, O Nwasokwa 1
PMCID: PMC38413  PMID: 8816831

Abstract

Electrogram recordings of ventricular fibrillation appear complex and possibly chaotic. However, sequences of beat-to-beat intervals obtained from these recordings are generally short, making it difficult to explicitly demonstrate nonlinear dynamics. Motivated by the work of Sugihara on atmospheric dynamics and the Durbin-Watson test for nonlinearity, we introduce a new statistical test that recovers significant dynamical patterns from smoothed lag plots. This test is used to show highly significant nonlinear dynamics in a stable canine model of ventricular fibrillation.

Full text

PDF
10495

Images in this article

10497Fig. 3
on p.10497

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bayly P. V., Johnson E. E., Wolf P. D., Greenside H. S., Smith W. M., Ideker R. E. A quantitative measurement of spatial order in ventricular fibrillation. J Cardiovasc Electrophysiol. 1993 Oct;4(5):533–546. doi: 10.1111/j.1540-8167.1993.tb01242.x. [DOI] [PubMed] [Google Scholar]
  2. Damle R. S., Kanaan N. M., Robinson N. S., Ge Y. Z., Goldberger J. J., Kadish A. H. Spatial and temporal linking of epicardial activation directions during ventricular fibrillation in dogs. Evidence for underlying organization. Circulation. 1992 Nov;86(5):1547–1558. doi: 10.1161/01.cir.86.5.1547. [DOI] [PubMed] [Google Scholar]
  3. Garfinkel A., Spano M. L., Ditto W. L., Weiss J. N. Controlling cardiac chaos. Science. 1992 Aug 28;257(5074):1230–1235. doi: 10.1126/science.1519060. [DOI] [PubMed] [Google Scholar]
  4. Kaplan D. T., Cohen R. J. Is fibrillation chaos? Circ Res. 1990 Oct;67(4):886–892. doi: 10.1161/01.res.67.4.886. [DOI] [PubMed] [Google Scholar]
  5. Nwasokwa O. N., Bodenheimer M. M. Global analysis of myocardial isotonic shortening: comparison with isometric dynamics. Am J Physiol. 1991 Feb;260(2 Pt 2):H486–H498. doi: 10.1152/ajpheart.1991.260.2.H486. [DOI] [PubMed] [Google Scholar]
  6. Sugihara G., Allan W., Sobel D., Allan K. D. Nonlinear control of heart rate variability in human infants. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2608–2613. doi: 10.1073/pnas.93.6.2608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sugihara G., May R. M. Nonlinear forecasting as a way of distinguishing chaos from measurement error in time series. Nature. 1990 Apr 19;344(6268):734–741. doi: 10.1038/344734a0. [DOI] [PubMed] [Google Scholar]
  8. Witkowski FX, Kavanagh KM, Penkoske PA, Plonsey R, Spano ML, Ditto WL, Kaplan DT. Evidence for determinism in ventricular fibrillation. Phys Rev Lett. 1995 Aug 7;75(6):1230–1233. doi: 10.1103/PhysRevLett.75.1230. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES