Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1983 Sep;80(18):5685–5688. doi: 10.1073/pnas.80.18.5685

Sensory distinction between H-2b and H-2bm1 mutant mice.

K Yamazaki, G K Beauchamp, I K Egorov, J Bard, L Thomas, E A Boyse
PMCID: PMC384323  PMID: 6577450

Abstract

Genetic polymorphism in the H-2:Qa:Tla region of chromosome 17 is associated with constitutive variation of bodily odor phenotypes which permit individual olfactory recognition among mice. To determine whether known genes in the H-2:Qa:Tla complex are concerned in the constitution of odor phenotypes, mice were tested for their ability to sense a difference between the B6/By (H-2b) and congeneic B6.C-H-2bm1 strains, which differ genetically by mutation of the H-2K gene. As in previous studies of the sensory discrimination of H-2:Qa:Tla phenotypes, mice were trained by reward in a Y maze to distinguish the odors of urine samples, and the successful distinctions of B6/By from B6.C-H-2bm1 were confirmed by transfer of training, without reward, to coded samples of urine from genetically equivalent urine donor mice which the trained mice had not previously encountered. Cosegregation of odor phenotype with H-2b and H-2bm1 was demonstrated by transfer of training to typed H-2b and H-2bm1 homozygous segregants of F2 generations of appropriate crosses. Although it is not excluded that the differences in odor phenotype which distinguish H-2b and H-2bm1 mice are directly related to the structure of the H-2b and H-2bm1 products, it is equally possible that H-2-related odor phenotypes arise from effects of H-2 genetic variation on metabolic pathways either directly, or indirectly through developmental polymorphism.

Full text

PDF
5685

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyse E. A., Beauchamp G. K., Yamazaki K., Bard J., Thomas L. Chemosensory communication. A new aspect of the major histocompatibility complex and other genes in the mouse. Oncodev Biol Med. 1982;4(1-2):101–116. [PubMed] [Google Scholar]
  2. Boyse E. A., Beauchamp G. K., Yamazaki K. Critical review: the sensory perception of genotypic polymorphism of the major histocompatibility complex and other genes: some physiological and phylogenetic implications. Hum Immunol. 1983 Apr;6(4):177–183. doi: 10.1016/0198-8859(83)90090-3. [DOI] [PubMed] [Google Scholar]
  3. Iványi P. Some aspects of the H-2 system, the major histocompatibility system in the mouse. Proc R Soc Lond B Biol Sci. 1978 Jun 5;202(1146):117–158. doi: 10.1098/rspb.1978.0060. [DOI] [PubMed] [Google Scholar]
  4. KLOEK J. Of the sexes. Psychiatr Neurol Neurochir. 1961 Sep-Oct;64:309–344. [PubMed] [Google Scholar]
  5. Melvold R. W., Kohn H. I., Dunn G. R. History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony. Immunogenetics. 1982;15(2):177–185. doi: 10.1007/BF00621950. [DOI] [PubMed] [Google Scholar]
  6. Schulze D. H., Pease L. R., Geier S. S., Reyes A. A., Sarmiento L. A., Wallace R. B., Nathenson S. G. Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A. 1983 Apr;80(7):2007–2011. doi: 10.1073/pnas.80.7.2007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Weiss E. H., Mellor A., Golden L., Fahrner K., Simpson E., Hurst J., Flavell R. A. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. Nature. 1983 Feb 24;301(5902):671–674. doi: 10.1038/301671a0. [DOI] [PubMed] [Google Scholar]
  8. Winoto A., Steinmetz M., Hood L. Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3425–3429. doi: 10.1073/pnas.80.11.3425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Yamaguchi M., Yamazaki K., Beauchamp G. K., Bard J., Thomas L., Boyse E. A. Distinctive urinary odors governed by the major histocompatibility locus of the mouse. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5817–5820. doi: 10.1073/pnas.78.9.5817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Yamazaki K., Beauchamp G. K., Bard J., Thomas L., Boyse E. A. Chemosensory recognition of phenotypes determined by the Tla and H-2K regions of chromosome 17 of the mouse. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7828–7831. doi: 10.1073/pnas.79.24.7828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Yamazaki K., Beauchamp G. K., Wysocki C. J., Bard J., Thomas L., Boyse E. A. Recognition of H-2 types in relation to the blocking of pregnancy in mice. Science. 1983 Jul 8;221(4606):186–188. doi: 10.1126/science.6857281. [DOI] [PubMed] [Google Scholar]
  12. Yamazaki K., Boyse E. A., Miké V., Thaler H. T., Mathieson B. J., Abbott J., Boyse J., Zayas Z. A., Thomas L. Control of mating preferences in mice by genes in the major histocompatibility complex. J Exp Med. 1976 Nov 2;144(5):1324–1335. doi: 10.1084/jem.144.5.1324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Yamazaki K., Yamaguchi M., Baranoski L., Bard J., Boyse E. A., Thomas L. Recognition among mice. Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types. J Exp Med. 1979 Oct 1;150(4):755–760. doi: 10.1084/jem.150.4.755. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES