Skip to main content
. Author manuscript; available in PMC: 2013 Dec 3.
Published in final edited form as: Nature. 2010 Aug 26;466(7310):10.1038/4661051a. doi: 10.1038/4661051a

Figure 1. Retinoblastoma and the cell cycle.

Figure 1

Dividing cells undergo cycles of division, in which the S phase (when DNA replicates) is separated from the M phase (when mitotic cell division occurs) by two gap phases, G1 and G2. The role of the retinoblastoma (Rb) protein in regulating the transition from G1 to the S phase is well established. Three studies3–5 now implicate this protein in mediating chromosome dynamics during the M phase. Outcomes of Rb deficiency during mitosis include chromosome gain, chromosome loss and chromosome breakage.