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. Author manuscript; available in PMC: 2013 Dec 3.

Published in final edited form as: Respirology. 2012 Nov;17(8):10.1111/j.1440-1843.2012.02247.x. doi: 10.1111/j.1440-1843.2012.02247.x

a) Effect of thoracic irradiation and captopril therapy on pulmonary vascular resistance (PVR). Values of PVR (mean±sem) calculated at a normalized flow of 100 mL/min/kg. Drug therapy groups received captopril (17 or 56 mg/kg/d) immediately or delayed 2-weeks after irradiation. Irradiation resulted in increased PVR. The vasoactive dose of captopril (56 mg/kg/d) mitigated the radiation-induced increase in PVR. (Number of rats in individual groups indicated on the bars, * p ≤ 0.033, ^ p ≤ 0.048, difference from bold marker). b) Example of the effect of thoracic irradiation and immediate captopril therapy (56 mg/kg/d) on PVR. The graph demonstrates multipoint pulmonary artery pressure (mean±sem) versus flow rate normalized to body weight. Measurements were made 2-months after irradiation (10 Gy limited to the thorax) in isolated perfused lungs. Combined data for each experimental group are fit to a simple distensibility model of PVR over the range of flow rates.

a) Effect of thoracic irradiation and captopril therapy on pulmonary vascular resistance (PVR). Values of PVR (mean±sem) calculated at a normalized flow of 100 mL/min/kg. Drug therapy groups received captopril (17 or 56 mg/kg/d) immediately or delayed 2-weeks after irradiation. Irradiation resulted in increased PVR. The vasoactive dose of captopril (56 mg/kg/d) mitigated the radiation-induced increase in PVR. (Number of rats in individual groups indicated on the bars, * p ≤ 0.033, ^ p ≤ 0.048, difference from bold marker). b) Example of the effect of thoracic irradiation and immediate captopril therapy (56 mg/kg/d) on PVR. The graph demonstrates multipoint pulmonary artery pressure (mean±sem) versus flow rate normalized to body weight. Measurements were made 2-months after irradiation (10 Gy limited to the thorax) in isolated perfused lungs. Combined data for each experimental group are fit to a simple distensibility model of PVR over the range of flow rates.