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. 2013 Sep 23;10:102. doi: 10.1186/1742-4690-10-102

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Copyright © 2013 van den Kerkhof et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Short V1 sequences and lower probability of overall glycosylation correlate with the development of cross-reactive neutralizing activity. Scatter plots of individual’s geometric mean IC₅₀ titer across the 6 virus panel (x-axis) versus sequence characteristics of the gp160s from clonal virus isolates on the y-axis. (A) length of gp160 in amino acids (AA); (B) length of variable region 1 (V1) in amino acids (AA); (C) total number of PNGS in gp160; (D) number of NXS motifs relative to the total number of PNGS.