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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1996 Sep 3;93(18):9704–9709. doi: 10.1073/pnas.93.18.9704

Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

C A Mallick-Wood 1, W Pao 1, A M Cheng 1, J M Lewis 1, S Kulkarni 1, J B Bolen 1, B Rowley 1, R E Tigelaar 1, T Pawson 1, A C Hayday 1
PMCID: PMC38493  PMID: 8790395

Abstract

Chimeric mice in which lymphocytes are deficient in the Syk tyrosine kinase have been created. Compared with Syk-positive controls, mice with Syk -/- lymphocytes display substantial depletion of intraepithelial gamma delta T cells in the skin and gut, with developmental arrest occurring after antigen receptor gene rearrangement. In this dependence on Syk, subsets of intraepithelial gamma delta T cells are similar to B cells, but distinct from splenic gamma delta T cells that develop and expand in Syk-deficient mice. The characteristic associations of certain T-cell receptor V gamma/V delta gene rearrangements with specific epithelia are also disrupted by Syk deficiency.

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Selected References

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