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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Pharmacol Biochem Behav. 2013 Oct 11;112:10.1016/j.pbb.2013.10.002. doi: 10.1016/j.pbb.2013.10.002

Figure 2.

Figure 2

Effects of medial nucleus accumbens stimulation or blockade of the 5-HT1A receptor on feeding, water intake, and locomotion. The 8 μg dose of the 5-HT1A agonist 8-OH-DPAT significantly reduced food and water intake across the 2-hr feeding session in food-restricted rats feeding on standard chow (A). Additionally, rearing behavior was reduced during the first 30 min for the 4.0 and 8.0 μg doses. Fewer food approaches were recorded during the first 30 min session following the highest 8-OH-DPAT treatment, though this was compensated for by an increase in head entries (compared to vehicle injections) during the second 30 min period. Ambulation was increased during the 60-90 min time frame for the 2.0 and 4.0 μg treatments of the agonist, though this did not interfere with feeding behavior. In contrast, antagonism of the 5-HT1A receptor with WAY 100135 had no effect on any of the behaviors measured here (B). *p < .05, **p < .01 for main drug effects; single and double crosses demark p < .05 and p < .01 for drug × time interaction effect, respectively. Stars above or within the bar graphs denote significant differences from the respective vehicle control injection, as assessed by Tukey’s HSD.