Abstract
Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) has been utilized to study energy, carbohydrate, and phospholipid metabolism in vitro and in vivo in live tissues non-invasively. Despite its lack of sensitivity, its application has extended to in situ human tissues and organs since proper signal localization was devised. Follow-up of phosphocreatine in neuromuscular diseases and schizophrenia and follow-up of phospholipid-related molecules in tumors are described here to demonstrate the value of 31P-MRS as an imaging technique to determine in vivo markers of disease and in the diagnosis, prognosis, and follow-up of human diseases.
Keywords: 31P MR spectroscopy, chemical shift imaging, in vivo metabolism, neuromuscular disease, mitochondrial cytopathy, schizophrenia, non-Hodgkin's lymphoma, chronic lymphocytic leukemia
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