Abstract
Epigenetics affects health, appearance and behavior and propagates mammalian phenotypes across generations. Nutrients, drugs and behavior can all direct changes in epigenetics. In at least some cases, these directed changes are propagated across generations. This range of influences on epigenetics suggests that epigenetics is highly interactive with the environment. Changes in the environment may regularly change epigenetics and influence our future responses to the environment. The current research challenge is to understand these influences and use them to direct epigenetics toward improved health and longevity.
Keywords: Maternal nutrition, epigenetics, imprinting, methylation, acetylation, DNA, histones, expression, behavior, stress, glucocorticoid, hypothalamic-pituitary-adrenal, glucose, diabetes, metabolomics, reproduction, development, diet, mouse, rat, fox, human, agouti, axin, star, phenotype, genotype, GATACCA
Full Text
The Full Text of this article is available as a PDF (238.9 KB).