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. 1996 Sep 3;93(18):9850–9857. doi: 10.1073/pnas.93.18.9850

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

P M Smallwood 1, I Munoz-Sanjuan 1, P Tong 1, J P Macke 1, S H Hendry 1, D J Gilbert 1, N G Copeland 1, N A Jenkins 1, J Nathans 1
PMCID: PMC38518  PMID: 8790420

Abstract

Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.

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