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. Author manuscript; available in PMC: 2014 Feb 21.
Published in final edited form as: Neuron. 2013 Aug 21;79(4):10.1016/j.neuron.2013.06.026. doi: 10.1016/j.neuron.2013.06.026

Figure 3. Accelerated PERIOD Rhythm Resynchronization in Eif4ebp1 KO Mice (see also Figure S3).

Figure 3

A and C. Representative microscopic images of PER2 (A) and PER1(C) immunostaining in the SCN. WT and Eif4ebp1 KO animals were entrained in a 12 h/12 h LD cycle for 10 days, and on the 11th day, the LD cycle was advanced for 6 h (light on at previous ZT18). Mice were sacrificed at ZT12 before and different days after the LD cycle shift. Representative images are shown before (Day 0) and 5 days after the LD cycle shift (Day 5). Scale bars: 100 μm. The quantitative data for all time points are shown in B (for PER2) and D (for PER1). PER levels at ZT12 on Day 0 are normalized to be “1” in WT and KO SCN, respectively. Values are presented as the mean ± SEM. Each data point is averaged from eight mice. #p<0.05 vs. Day 0; *p<0.05 vs. WT by ANOVA.