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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Neuroscience. 2013 Aug 29;254:10.1016/j.neuroscience.2013.08.033. doi: 10.1016/j.neuroscience.2013.08.033

Fig. 11. 3α,5β-THP increases anxiety after METH withdrawal in rats: reversal by flumazenil.

Fig. 11

Anxiety-like behavior was tested using the acoustic startle response (ASR) across METH treatments. All animals were injected with 3α,5β-THP (10 mg/kg, i.p.) or oil vehicle 20 min. before testing. A, ASR in vehicle or 3α,5β-THP-injected rats. Mean ± SEM, 2-factor ANOVA, F(7,61)=19.51, P<0.0001; *P<0.05 vs. all other vehicle-treatment groups; †P<0.05 vs. all other 3α,5β-THP -treatment groups; n=9 rats/group. B, 3α,5β-THP effects on the ASR across METH treatment groups. Mean ± SEM, 1-factor ANOVA, F(3,31)=47.7, P<0.0001; *P<0.05 vs. all other groups, n=9 rats/group. 3α,5β-THP increased the startle response only after a 24 h METH Wd (90% of animals), while Flu prevented this effect.