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International Journal of General Medicine logoLink to International Journal of General Medicine
. 2013 Dec 6;6:905–909. doi: 10.2147/IJGM.S54559

The prevalence and reliability of self-reported penicillin allergy in a community hospital

Faisal A Khasawneh 1,, Megan A R Slaton 2, Stephen L Katzen 2, Ashley A Woolbert 2, Sean D Anderson 2, Michelle B Parker 2, Rachel M Anderson 2, Krystal K Haase 3, Roger D Smalligan 4
PMCID: PMC3857164  PMID: 24348066

Abstract

Background

Penicillin (PCN) accounts for most cases of antibiotic allergies. Reported PCN allergy deprives the patient from this class of antibiotics and creates hesitancy in using other beta-lactam antibiotics. The aim of this study is to report the prevalence of self-reported PCN allergy among adult patients admitted to the hospital and to examine the probable validity of these reports.

Methods

A questionnaire was conducted among 192 patients with self-reported PCN allergy who were admitted to a community hospital between July 25, 2011 and January 25, 2012. Patients admitted with an infection and treated with a beta-lactam were also followed until hospital discharge.

Results

The mean age of patients at the time of their self-reported allergic reaction was 20.3 years. The most common allergic symptoms reported in decreasing order of frequency were itchy rash, angioedema, and urticaria. Based on analysis of the questionnaires, 121 patients (63.0%) had probable PCN allergy, 54 (28.1%) had possible PCN allergy, and 17 (8.9%) were unlikely to have a PCN allergy. Fifty-one participants (26.6%) had self-reported subsequent exposure to PCN in their life. This subsequent exposure was well tolerated in 86.3% of the participants. Fifty participants (25.9%) had self-reported subsequent exposure to a first generation cephalosporin and it was well tolerated in 78.4% of them.

Conclusion

Taking a detailed history from patients with self-reported PCN allergy can help to distinguish a true PCN allergy from a false positive report of allergy and hence allow clinicians to use this important class of antibiotics when truly indicated.

Keywords: penicillins, beta-lactam antibiotics, allergy

Introduction

Antibiotic allergy accounts for a small but significant proportion of adverse drug reactions.1,2 These allergic reactions are immunologically mediated and can affect multiple organ systems with variable degrees of severity.3 The most common allergic reactions to antibiotics are rashes, including urticaria, and pruritus.4,5 After first exposure to an antibiotic there is typically a period of sensitization ranging from days to weeks before an adverse reaction is noted.6 On subsequent exposure to the same antibiotic in a previously sensitized person the allergic reaction can appear within minutes to hours.

The majority of antibiotic allergies are self-reported.7 The most common antibiotic patients report as an allergy is penicillin (PCN).7 Penicillins and other beta-lactam antibiotics are the cornerstone of empiric antibiotic regimens for life threatening infections and are the preferred treatment for many infections once culture and sensitivity results are identified.810 Reported allergy to PCN, if inaccurate, deprives patients of this important class of antibiotics and makes clinicians hesitant to use other beta-lactam antibiotics out of fear from cross-allergy.

This study was designed to measure the prevalence and probable accuracy or reliability of reported PCN allergy among adult inpatients admitted to a busy teaching internal medicine service in West Texas. Furthermore, the reliability of the self-reported PCN allergy was tested by obtaining detailed history supporting true allergic reaction and by examining the medical records for documented reactions after beta-lactam antibiotics exposure during the patients’ current hospitalization.

Methods

This was a prospective observational study conducted at Northwest Texas Hospital (NWTH) in Amarillo, Texas on the Tech University Health Sciences Center (TTUHSC) internal medicine service. NWTH is a 400 bed community teaching hospital in Amarillo, Texas. The study was approved by the Institutional Review Boards for both TTUHSC and NWTH. Between July 25, 2011 and January 25, 2012 the investigators reviewed the medical records of all newly admitted TTUHSC patients on a daily basis, specifically looking for documentation of a reported PCN allergy in the nursing, pharmacy, and physician sections. Patients with allergy to beta-lactams other than PCN were not included. Patients with an alleged PCN allergy were invited by the investigators to participate in the study and were asked to sign an informed consent document. In the event of the patient being unable to answer questions (due to intubation, critical illness, or delirium), their next of kin were approached and asked to participate. Subjects were interviewed using a standardized questionnaire (Table 1).

Table 1.

Standardized questionnaire used in the study

1. What was the patient’s age at the time of the reaction?
2. Does the patient recall the reaction? If not, who informed him of it?
3. How long after starting the PCN course did the reaction begin?
4. What were the characteristics of the reaction?
5. What was the route of antibiotic administration?
6. Why was PCN prescribed for the patient?
7. Has the patient taken any of the following beta-lactam antibiotics: amoxicillin, amoxicillin/clavulanate, or cephalexin after his/her initial PCN allergic reaction? If yes, did he/she have a reaction to it?

Abbreviation: PCN, penicillin.

The patient’s age, sex, other antibiotic allergies, and reason for admission were collected from medical records. Patients admitted with an infection and who were being treated with a beta-lactam antibiotic were followed prospectively throughout their admission for any sign of allergic reaction attributed to that antibiotic.

Based on the participants’ answers to the questionnaire, patients were divided into one of three categories: 1) probable PCN allergy; 2) possible PCN allergy; or 3) unlikely to have PCN allergy. Criteria for placement in each of the categories above were as follows: 1) probable PCN allergy: if the reaction was a) documented in the medical record of a previous admission to NWTH, b) if the same type of reaction had occurred on two different occasions after exposure to PCN, or c) if the patient’s reported signs and symptoms were consistent with an allergic reaction (itchy rash, urticaria, angioedema, bronchospasm, or anaphylactic shock); 2) possible PCN allergy: if the patient reported a) a nonitchy rash only, b) typical signs/symptoms (itchy rash, urticaria, angioedema, bronchospasm, or anaphylactic shock) with uneventful subsequent exposure to PCN, or c) if the patient could not recall the signs or symptoms that caused him/her to be labeled PCN allergic; and 3) unlikely to have PCN allergy: if the patient reported signs or symptoms consistent with a known side effect of PCN and was mistakenly labeled as allergic.

Statistical analysis

For continuous variables, the mean with standard deviation was reported. For categorical variables, the number of patients with that variable and a corresponding percentage were reported. Univariate comparisons between the above three patient categories were performed by ordered logistic regression (robust). A P-value of less than 0.05 was considered statistically significant. The statistical analysis was done using Stata 12 (StataCorp LP, College Station, TX, USA).

Results

During the study period, 2,589 patients were admitted to NWTH on the TTUHSC internal medicine service. Self-reported PCN allergy was found to be documented in the charts of 387 (14.9%) patients. After being asked to participate in the study, 192 patients (49.6%) consented and answered the questionnaire, 89 patients (23.0%) declined, 3 patients (0.8%) did not speak English, 26 patients (6.7%) had mental status changes and no next of kin was available to consent, 19 patients (4.9%) died before being approached by the investigators, and 58 patients (15.0%) were discharged before being approached to participate. The patient provided the information in 127 of the encounters (66.1%), while next of kin (spouse in 15 cases, parents in 11 cases, and a sibling in 7 cases) was the source of information in the rest. After applying the above criteria to the provided answers in the questionnaires, 121 patients (63.0%) were classified as probable PCN allergy, 54 patients (28.1%) as possible PCN allergy, and 17 patients (8.9%) as unlikely to have PCN allergy. The characteristics of each group are shown in Table 2.

Table 2.

The characteristics of 192 patients with reported penicillin allergy

Characteristic Probable PCN allergy Possible PCN allergy Unlikely PCN allergy Groups difference (ordered logistic regression [robust])
Number of patients 121 54 17
Age (years ± SD) 55.1±17.0 55.6±17.2 55.4±13.6 P=0.874
Sex P=0.136
 Male 50 25 11
 Female 71 29 6
Onset of allergic reaction* P=0.112
 Childhood (≤10 yrs) 42 27 6
 11–19 yrs 25 8 0
 Adulthood (≥20 yrs) 53 18 11
Route of exposure** P=0.643
 Intramuscular inj 62 25 5
 Intravenous inj 13 8 1
 Oral 40 14 9
Time from exposure to allergic reaction*** P=0.012
 Within 24 hours 76 22 7
 After 24 hours 24 14 8
Tolerated PCN on subsequent exposure 0 out of 7 37 out of 37 5 out of 5 NA
Tolerated cephalexin on subsequent exposure 19 out of 28 18 out of 20 3 out of 3 P=0.049
Admitted with an infection 25 11 6 P=0.477
Received a beta-lactam 14 6 5 P=0.284
Other antibiotic allergies 24 9 3 P=0.637

Notes:

*

Denotes that two patients could not remember the age at which they had the penicillin allergic reaction;

**

denotes that 15 patients could not remember the route of penicillin exposure;

***

denotes that 41 patients could not remember the time from penicillin exposure to allergic reaction.

Abbreviations: inj, injection; NA, not applicable; PCN, penicillin; SD, standard deviation.

The mean age of patients at the time of allergic reaction was 20.3±15.0 years. The most common reasons for having been prescribed PCN were pharyngitis and other respiratory tract infections, which accounted for 44% of cases. The most common allergic symptoms reported were itchy rash followed by angioedema and urticaria. Reported side effects mislabeled as allergic reactions were abdominal pain, heart burn, nausea, vomiting, hair loss, confusion, and seizures.

Thirty-six patients reported allergies to other antibiotics in the following order: sulfa, cephalosporins, erythromycin, fluoroquinolones, tetracycline, vancomycin, and metronidazole. Forty-nine patients (26.6%) with alleged PCN allergy reported subsequent exposure to amoxicillin or amoxicillin/clavulanate, including seven patients with probable PCN allergy, and 42 of them (85.7%) tolerated it well. None of the above mentioned seven patients with probable PCN allergy tolerated subsequent PCN exposure. Fifty-one patients (26.6%) with alleged PCN allergy reported subsequent exposure to cephalexin, including 19 patients with probable PCN allergy, and 40 of them (78.4%) tolerated it well.

Forty-two patients (21.9%) were admitted to the hospital with an infection. All of the 24 patients who received a broad spectrum (third generation and above) cephalosporin (16 patients) or a carbapenem (8 patients) tolerated it well. One patient with probable PCN allergy received aztreonam and, expectedly, tolerated it well.

Discussion

Previous reports in the medical literature have estimated that 10%–20% of patients with a self-reported PCN allergy are ultimately found to be truly allergic when assessed by skin testing.11 The reasons behind this over reporting of PCN allergy include patient confusion of side effects for allergic reactions, being informed of their alleged allergy by a parent without a firsthand recall of the reaction, and loss of the specific immunoglobulin E (IgE) conferring PCN allergy.12,13 As demonstrated, taking a detailed history in these cases may allow clinicians to exclude true PCN allergy, permitting patients to receive the antibiotic in question without serious sequelae. Patients with a concerning history for a serious allergic reaction and a compelling need for that antibiotic should undergo skin testing and subsequent PCN desensitization if indicated.3,14 Figure 1 demonstrates how we have incorporated the findings of this study into our practice.

Figure 1.

Figure 1

Algorithm incorporating the current study findings in clinical practice.

Abbreviation: PCN, penicillin.

It has been demonstrated that the majority of IgE-mediated reactions occur within 1 hour of PCN exposure and that they rarely develop after 72 hours.6 Hence, one of the questions used to help determine if a reaction was likely to be related to PCN exposure was the time from exposure to developing the reaction. In our population, patients ultimately deemed to have either a probable or possible PCN allergy were more likely to display signs and symptoms consistent with allergy within 24 hours of exposure, as compared to patients felt unlikely to have PCN allergy (P=0.012).

An often mentioned concern of clinicians when discussing PCN allergy is the possibility of cross-allergy with cephalosporins.15,16 PCN and cephalosporins have similar beta-lactam rings but the beta-lactam rings of cephalosporins undergo a more rapid fragmentation in vivo than those of PCNs making immunologic cross-reactivity uncommon.17 Several studies have suggested that PCN and cephalosporin cross-reactivity depends on sharing similar side chain substitutes rather than similar beta-lactam rings.18 Higher PCN-cephalosporin cross-allergy rates previously reported have been attributed to PCN test compounds being contaminated with cephalosporins.19 Patients with true PCN allergy have a 3-fold increase in adverse antibiotic reactions in general, irrespective of any noted structural similarity.6

Cephalosporins themselves cause allergic reactions among 1%–3% of patients, whether the patient is allergic to PCN or not.19 Currently, cross-allergy between PCN and cephalosporins is uncommon, occurring in less than 5% of cases, with the majority of these reactions being found between PCN and first generation cephalosporins rather than between PCN and advanced generation cephalosporins.15 This fact held true in our study where patients with probable PCN allergy were more likely to have a reaction to cephalexin (first generation cephalosporin) on subsequent exposure compared to patients with possible or unlikely PCN allergy (P=0.049). In addition, there was no cross-allergy between PCN and the third and fourth generation cephalosporins seen in our cohort of patients.

Carbapenems were well tolerated in our study group. Romano et al tested meropenem tolerance among patients with IgE-mediated hypersensitivity to PCN and found that among 104 patients with a positive PCN skin test only one patient had a positive skin test to meropenem (cross-allergy prevalence of 0.9%).20 All patients with a negative meropenem skin test also had no reaction to a subsequent intravenous meropenem challenge. In a similar study of imipenem involving 112 patients with immediate hypersensitivity to PCN, only one patient (0.9%) had a positive skin test and the remainder tolerated an intramuscular imipenem challenge without any clinical reaction.21

The current study has several limitations. First, recall bias was a factor since patients may or may not have remembered allergic symptoms and subsequent antibiotic exposures accurately. This problem was compounded when the allergy history had to be obtained from a family member due to the patient being ventilated or incapacitated in some way. The second limitation was the lack of PCN skin testing to provide further confirmation or clarification of the designated patient groups. At the time of the study, the now commercially available product Pre-pen® (ALK, Round Rock, TX, USA) which can be used for PCN skin testing at the bedside was not available due to a national shortage. Thirdly, the focus of the study was limited to life threatening IgE-mediated “type I” allergic reactions. Symptoms and signs suggesting antibody mediated, immune complex mediated and delayed hypersensitivity reactions were not sought.

In conclusion, taking a detailed history from patients with self-reported PCN allergy by focusing on allergic symptoms and subsequent PCN exposure can help exclude true allergy and allow the use of this important class of antibiotics when clinically indicated. Furthermore, this study supports the concept that patients with self-reported PCN allergy generally tolerate other beta-lactam antibiotics well, with minimal risk of cross-allergy.

Footnotes

Disclosure

All authors report no conflicts of interest in this work.

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