TABLE 2.
Patient Characteristics, TS mRNA Expression, and Survival
| Patient characteristics
|
TS by RT-PCR
|
|||||
|---|---|---|---|---|---|---|
| No. (92) | Median overall survival, mo | Log-rank P | Median | No. (85) | Kruskal-Wallis P | |
| Stage | ||||||
| IA | 39 | NR | .671 | 3.42 | 37 | .642 |
| IB | 53 | 74.9 | 3.65 | 48 | ||
| Histology | ||||||
| Adeno | 41 | 62.2 | .642 | 2.25 | 39 | .002 |
| BAC | 7 | 87.4 | 0.50 | 6 | ||
| Squamous | 33 | NR | 4.73 | 30 | ||
| Large cell | 11 | 69.4 | 5.08 | 10 | ||
| Performance status | ||||||
| 0 | 52 | 80.4 | .771 | 3.47 | 52 | .853 |
| 1–2 | 33 | 62.1 | 3.87 | 26 | ||
| Weight loss, >5% in 3 mo | ||||||
| Absent | 75 | 80.4 | .020 | 3.52 | 69 | .703 |
| Present | 6 | 34.1 | 5.60 | 6 | ||
| Smoking status | ||||||
| Never | 6 | 31.2 | .898 | 4.53 | 4 | .057 |
| Quit | 55 | 74.9 | 2.26 | 51 | ||
| Active | 27 | 88.2 | 5.16 | 26 | ||
| Sex | ||||||
| Women | 39 | 88.2 | .605 | 4.04 | 35 | .652 |
| Men | 53 | 74.9 | 2.33 | 50 | ||
TS indicates thymidylate synthase; RT-PCR, reverse-transcriptase polymerase chain reaction; NR, not reached.