Figure 7.

Cholesterol accumulates in the vicinity of amyloid-beta peptide (Aβ) deposits in 3 × Tg-Alzheimer's disease (AD) mouse model brain tissue sections. Images of two areas located in the superior subiculum show the time-of-flight secondary ion mass spectrometry (TOF-SIMS) cholesterol distribution (a–c) and the overlaid cholesterol/p-FTAA images (b–d) (p-FTAA is an amyloidotropic fluorescent dye that binds primarily to fibrillary Aβ). Cholesterol accumulations are highlighted by white arrowheads in (a–c). Reproduced with permission (Sole-Domenech et al, 2013)