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. 1996 Aug 20;93(17):8968–8970. doi: 10.1073/pnas.93.17.8968

Interleaflet clear space is reduced in the membrane of COP I and COP II-coated buds/vesicles.

L Orci 1, R Schekman 1, A Perrelet 1
PMCID: PMC38578  PMID: 8799137

Abstract

Intracellular transfers between membrane-bound compartments occur through vesicles that bud from a donor compartment to fuse subsequently with an acceptor membrane. We report that the membrane that delimits COP I or COP II-coated buds/vesicles from the endoplasmic reticulum and the Golgi complex has a thinner interleaflet clear space as compared with the surrounding, noncoated parental membrane. This change is compatible with a compositional change of the membrane bilayer during the budding process.

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Selected References

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