Figure 6. PCa cells exposure to epigenetic modulating drugs and resveratrol promotes the physical and direct interaction between sirtuin 1 and H2A.Z.

(A) PLA assay for PC-3 after exposure to 0.5μM TSA, alone or combined with 1μM 5-aza-dC, and 40μM resveratrol (40x magnification). (B) Analysis of PLA results represented as number of signals per cell (mean±SD, n=50). Dunnet's test: ****p<0.0001.