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. 2012 May;64(3):229–235. doi: 10.1016/S0019-4832(12)60078-9

Patterns and determinants of dyslipidaemia in ‘Young’ versus ‘Not so Young’ patients of coronary artery disease: a multicentric, randomised observational study in northern India

Nakul Sinha a,*, Sudeep Kumar b, Himanshu Rai c, Neha Singh c, Aditya Kapoor d, Satyendra Tewari b, RK Saran e, VS Narain f, RPS Bharadwaj g, RK Bansal g, PC Saxena h, PR Sinha i, PR Gupta j, Mukul Mishra k, Praveen Jain l, CM Pandey m, Uttam Singh n, SS Agarwal o
PMCID: PMC3860771  PMID: 22664802

Abstract

Aims

The aims of the study were to ascertain difference in lipid levels of ‘Young’ onset of coronary artery disease (CAD) (≤ 45 years) vs. ‘Not so Young’ onset of CAD (≥ 55 years) among north Indians and also to investigate determinants of ‘dyslipidaemia’ in CAD patients.

Methods

This was a prospective, multicentric, randomised, observational study carried in eight centres of UP, India. All blood investigations were performed employing a central laboratory.

Results

Out of a total 435 patients studied, 218 were in the ‘young group’ (YG) and 235 were in the ‘Not so Young Group’ (NSYG). Dyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG. Diabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG.

Conclusion

We conclude that lipid levels among north Indians are significantly higher in younger patients with CAD when compared with elderly.

Keywords: Cholesterol, Dyslipidaemia, Young CAD

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